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妊娠期糖尿病筛查必需空腹进行?NEJM最新研究揭示答案
近日,《新英格兰医学杂志》在线发表了美国Kaiser Permanente Northwest健康研究中心Teresa A. Hillier团队名为“A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening”的研究成果。该研究比较了妊娠期糖尿病的两种筛查方法,发现虽然这两种检查方式检出率有差异,但对孕产妇预后的影响无明显差异。[查看]
http://cxbio.com/Article/rsqtnbscbxkfjxnejmzx_1.html
抑郁患者慢性疼痛的原因找到了!Nature子刊揭示不同的丘脑皮质回路是引起异常性疼痛的基础
2021年3月8日,中国科学技术大学张智、李娟和晋艳研究团队合作在出版的《自然-神经科学》杂志上发表了一项新成果:Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states。他们发现,不同的丘脑皮质回路是由组织损伤和抑郁样状态引起的异常性疼痛的基础。[查看]
http://cxbio.com/Article/yyhzmxttdyyzdlnature_1.html
糖尿病患者的福音来了!《BMC》发文:NCAS可作为饮食糖替代品
近日,《BMC》发布了一篇题为High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice的文章,发现人和小鼠短期内食用糖精量在最大可接受水平(ADI)时,不会改变其肠道菌群稳态或引起葡萄糖耐受不良。[查看]
http://cxbio.com/Article/tnbhzdfyllbmcfwncask_1.html
Science:老年人优先接种SARS-CoV-2疫苗更可能降低死亡率
近日,《science》杂志发表了一篇题为Model-informed COVID-19 vaccine prioritization strategies by age and serostatus的文章,通过数字模型对全球不同国家的不同接种策略的效益做出了预测,发现60岁及以上的人群优先接种疫苗可以最大程度地减少死亡率。[查看]
http://cxbio.com/Article/sciencelnryxjzsarsco_1.html
Science:新冠突变毒株可能逃避中和抗体治疗,包括再生元和礼来的产品
1月25日,美国华盛顿大学、哈佛医学院布莱格姆妇女医院以及霍华德?休斯医学研究所的研究人员在《Science》共同发布了一项题为“Prospective mapping of viral mutations that escape antibodies used to treat COVID-19”的研究报告。文中绘制了“逃避”现有的主要临床抗体药物的病毒突变图谱,涵盖再生元的两款抗体药物以及礼来的一款抗体药物,表明这些药物可能对SARS-CoV-2发生的一些突变无效。[查看]
http://cxbio.com/Article/sciencexgtbdzkntbzhk_1.html
Science子刊:利用智能手机超灵敏定量检测唾液中的新冠病毒
根据一项新的研究,一种基于唾液的便携式智能手机平台为COVID-19测试提供了一种超灵敏但易于使用的方法,它可以在15分钟内给出测试结果,而无需进行当前金标准所需的资源密集型实验室测试。该方法在12名COVID-19感染者和6名健康对照者中进行了测试。相关研究结果于2020年12月11日在线发表在Science Advances期刊上,论文标题为“A smartphone-read ultrasensitive and quantitative saliva test for COVID-19”。论文通讯作者为美国杜兰大学医学院的Tony Y. Hu博士。[查看]
http://cxbio.com/Article/sciencezklyznsjclmdl_1.html
Science子刊解读!空气污染真会让COVID-19的流行变得更加致命吗?
近日,一篇刊登在国际杂志Science Advances上题为“Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis”的研究报告中,来自哈佛大学陈曾熙公共卫生学院等机构的科学家们通过研究发现,长期暴露于空气污染物中的人群或许更易死于COVID-19。在对美国超过3000个县的分析中,研究人员发现,长期暴露于细小颗粒物(PM2.5)的暴露量只要发生小幅增加,人群死于COVID-19的风险就会增加10%以上。[查看]
http://cxbio.com/Article/sciencezkjdkqwrzhrco_1.html
Mol Psych:研究揭示S<font color='red'>TAT</font>3有助于调节情绪
大量科学研究表明,炎症过程在精神疾病的发展中起着关键作用。特别感兴趣的领域之一IL-6 / STAT3信号转导途径,其与抑郁症,精神分裂症和双相情感障碍有关。在《Molecular Psychiatry》杂志上发表的一项研究中,由神经生理学和神经药理学部的Daniela Pollak领导的MedUni Vienna研究人员表明,STAT3作为一种控制情绪反应的分子,在传递5-羟色胺相关信号系统中起着重要作用。[查看]
http://cxbio.com/Article/molpsychyjjsstat3yzy_1.html
Nature:揭示摄入更多乳酸的黑色素瘤细胞是转移高手
在一项新的研究中,来自美国德克萨斯大学西南医学中心的研究人员发现某些黑色素瘤细胞更可能在体内扩散的原因。这一发现开辟了一种潜在的新治疗途径,并且可能用于帮助减少从3期黑色素瘤进展为更加致命的4期黑色素瘤的患者比例。相关研究结果近期发表在Nature期刊上,论文标题为“Metabolic heterogeneity confers differences in melanoma metastatic potential”。论文通讯作者为德克萨斯大学西南医学中心儿童医学中心研究所主任Sean Morrison博士和德克萨斯大学西南医学中心儿童医学中心研究所教授Ralph DeBerardinis博士。[查看]
http://cxbio.com/Article/naturejssrgdrsdhsslx_1.html
Nat Med:利用多能性干细胞移植在动物中生长出功能齐全的肺部
在一项新的研究中,来自美国哥伦比亚大学的研究人员能够使用移植的干细胞在小鼠胚胎中生长出功能齐全的肺部。这一发现表明人们最终有可能使用这种技术在动物中为需要肺部移植的患者生长出人肺部,以及研究新的肺部治疗方法。相关研究结果于2019年11月7日在线发表在Nature Medicine期刊上,论文标题为“Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells”。[查看]
http://cxbio.com/Article/natmedlydnxgxbyzzdwz_1.html
Acta Neuropathol:揭示帕金森病在脑细胞之间扩散新机制
在一项新的研究中,来自瑞典林雪平大学、卡罗林斯卡研究所、乌普萨拉大学和德国埃尔兰根大学医院的研究人员发现,神经细胞之间的较小通道参与了一种新发现的关于帕金森病如何在大脑中扩散的机制。这些结果表明有害的蛋白聚集物或者说沉积物能够结合通道形成蛋白并“搭便车”,并以这种方式扩散至健康细胞。相关研究结果近期发表在Acta Neuropathologica期刊上,论文标题为“Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes”。[查看]
http://cxbio.com/Article/actaneuropatholjspjs_1.html
Nature:揭示卵细胞选择最健康的线粒体传递给后代的机制
发育中的卵细胞会进行测试,选出最健康的线粒体(细胞中的能量制造工厂),然后传递给下一代。一项针对果蝇的新研究显示了这种测试是如何进行的。相关研究结果于2019年5月15日在线发表在Nature期刊上,论文标题为“Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline”。[查看]
http://cxbio.com/Article/naturejslxbxzzjkdxlt_1.html
国际联合委员会在东京举办评审和质量改进见习培训会
国际联合委员会(Joint Commission International,简称JCI)宣布将于2018年12月3-7日举办东京国际评审和质量改进见习培训会(Tokyo International Practicum on Accreditation and Quality Improvement)。为帮助希望取得JCI认证的医疗保健组织做好准备工作,这项全面的教育计划会详细解释JCI的方法和标准,并重点介绍要通过认证和成功做到以患者为中心需要遵循的最佳实践和流程。[查看]
http://cxbio.com/Article/gjlhwyhzdjjbpshzlgjj_1.html
Science:揭示天然的多反应性IgA识别微生物群机制
IgA被认为包被着驻留在肠道中的共生微生物群(commensal microbiota),并且抵抗肠道病原菌。IgA反应是在正常的稳态条件下发生的,而且在诸如派尔集合淋巴结(Peyer’s patches)之类的粘膜相关淋巴组织中参与T细胞依赖性的和T细胞不依赖性的分化通路。然而,尽管稳态IgA(homeostatic IgA)是大量存在的,但是它的反应特异性长期以来却是未知的。[查看]
http://cxbio.com/Article/sciencejstrddfyxigas_1.html
Science:高通量分析上千种微型蛋白,有望引发蛋白工程变革
在一项新的研究中,来自美国华盛顿大学和加拿大多伦多大学的研究人员报道了一种新的高通量方法使得对计算设计蛋白(computationally designed protein,即利用计算方法设计蛋白)的折叠稳定性进行最大规模的测试成为可能。[查看]
http://cxbio.com/Article/sciencegtlfxsqzwxdby_1.html
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