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双特异性抗体：开启肿瘤治疗新时代 [行业新闻]

: 综述全面阐述了双特异性抗体（BsAbs）在肿瘤治疗中的革命性进展，重点分析了其结构设计（如IgG样/非IgG样）、作用机制（桥接型/抗原交联型/辅因子模拟型）及17种已获批BsAbs的临床数据。[查看]; http://cxbio.com/Article/styxktkqzlzlxsd_1.html

轴突tau蛋白选择性减少改善阿尔茨海默病小鼠模型中的tau和淀粉样蛋白病理 [行业新闻]

: 德国维尔茨堡大学医院(University Hospital Wuerzburg)的Abdolhossein Zare和Saeede Salehi等研究人员开展了一项突破性研究。他们发现RNA结合蛋白hnRNP R能特异性结合tau编码基因Mapt mRNA的3'非翻译区(3'UTR)，促进其在轴突中的定位和局部翻译。通过构建hnRNP R基因敲除小鼠与5xFAD AD模型小鼠杂交，研究人员观察到这些小鼠大脑中磷酸化tau聚集和Aβ斑块显著减少。[查看]; http://cxbio.com/Article/20250730_industrialnews_1.html

SCREEN-WELL(R) 代谢型谷氨酸能配体化合物库 SCREEN-WELL(R) Metabotropic Glutamatergic ligand library [生命科学]

: SCREEN-WELL(R) 代谢型谷氨酸能配体化合物库 SCREEN-WELL(R) Metabotropic Glutamatergic ligand library, 提供了简单，方便的方法进行化合物筛选。每个化合物库包括：某一类化合物归为一个化合物库，包括抑制剂，激动剂或者诱导剂。每一个化合物库提供相关文件，介绍化合物的活性，在板上的位置，物理信息还有一份结构数据（SD）文件。可单独大量提供某种化合物。[查看]; http://cxbio.com/Article/Metabotropic-Glutamatergic-ligand-library_1.html

SCREEN-WELL(R) GABA能配体化合物库 SCREEN-WELL(R) GABAergic ligand library [生命科学]

: SCREEN-WELL(R) GABA能配体化合物库 SCREEN-WELL(R) GABAergic ligand library，有56种配体组成，包括内源性神经递质、激动剂、拮抗剂和商业化的药物。该化合物库非常适合于筛选或者识别GPCR、目标验证、第二轮筛选、建立新的鉴定方法和其他药理学运用。GABA能配体是更大规格的神经递质化合物库（BML-2810,包括含有680种枢神经系统受体配体）的组成成分之一。[查看]; http://cxbio.com/Article/GABAergic-ligand-library_1.html

小鼠GABA能神经元发育中前体细胞成熟能力的时序调控机制解析 [行业新闻]

: 在哺乳动物大脑发育过程中，GABA能抑制性神经元的多样性产生是一个精妙调控的过程。Max Planck Society的研究团队在《Nature Neuroscience》发表的研究中，通过多组学方法揭示了这一过程的分子机制。他们发现虽然GE前体细胞在整个发育过程中保持稳定的分化能力，能够持续产生相同的神经元亚型，但这些神经元亚型的成熟速度却会随着发育阶段而变化。这种"成熟能力"的时序变化主要由染色质重塑和NFIB转录因子调控网络驱动。[查看]; http://cxbio.com/Article/20250709_industrialnews_1.html

晨练与午练对2型糖尿病患者血糖和炎症标志物的差异化影响：一项随机交叉试验研究 [行业新闻]

: 研究发现，与晨练相比，午练能更有效维持血糖稳定，且与较低的皮质醇和炎症标志物(CRP、NT-proBNP)水平相关。该研究为优化糖尿病运动干预时间提供了临床依据，发表于《Diabetologia》。[查看]; http://cxbio.com/Article/20250630 _industrialnews_1.html

双靶点mTORC1/2抑制剂onatasertib联合PD-1抗体toripalimab治疗晚期实体瘤的多中心I/II期临床研究 [行业新闻]

: 免疫检查点抑制剂(CPI)虽革新了肿瘤治疗格局，但PD-1/PD-L1抗体单药治疗仅能使部分患者获益。在宫颈癌领域，即使PD-L1阳性患者接受pembrolizumab治疗的客观缓解率(ORR)不足20%，而PD-L1阴性患者几乎无响应。与此同时，PI3K-AKT-mTOR通路的异常激活在多种肿瘤中被证实可促进免疫逃逸，临床前研究显示mTOR抑制剂能通过调节肿瘤微环境(TME)增强PD-1抗体疗效，但缺乏临床证据支持。[查看]; http://cxbio.com/Article/20250626_industrialnews_1.html

单细胞多组学揭示FABP1+ 肾细胞癌通过脂肪酸重编程激活PLG-PLAT轴驱动肿瘤血管生成 [行业新闻]

: 福建医科大学附属第一医院的研究团队在《Molecular Cancer》发表创新性研究，通过单细胞多组学技术结合功能实验，首次揭示FABP1+肿瘤亚群通过PLG-PLAT信号轴促进血管生成的分子机制。[查看]; http://cxbio.com/Article/20250617_INDUSTRIALNEWS_1.html

AquaBlot (TM) 10xHigh Efficiency Transfer Buffer 高效转膜buffer [生命科学]

: AquaBlot (TM) 10xHigh Efficiency Transfer Buffer 高效转膜buffer, 是转膜效率比传统的Towbin（Tris-甘氨酸）buffer更优异的10×转膜buffer。请用去离子水10倍稀释后使用。在制备过程中无需添加甲醇。[查看]; http://cxbio.com/Article/AquaBlot-Buffer_1.html

免疫组化笔/ 免疫组化（迷你）笔 IHC PAP pen / IHC PAP (mini) pen [生命科学]

: 使用免疫组化笔IHC PAP Pen在载玻片上的样本周围画圆圈，可提供一层疏水屏障。本产品适用于PAP、ABC、免疫荧光法、冰冻切片和原位杂交。[查看]; http://cxbio.com/Article/IHC-PAP-pen_1.html

阿尔茨海默病SIRT2酶与记忆修复的希望 [行业新闻]

: 韩国基础科学研究所（IBS）的一个研究团队发现了一种之前未知的酶SIRT2，它在与阿尔茨海默病（AD）相关的记忆丧失中起着关键作用。该研究由IBS认知与社会性研究中心主任李政勋（C Justin LEE）领导，为理解星形胶质细胞如何通过产生过量的抑制性神经递质GABA来促进认知能力下降提供了重要见解。[查看]; http://cxbio.com/Article/aechmbsirt2myjyxfdxw_1.html

体内释放的Anandamide可缓解疼痛 [生命科学]

: Anandamide（N-花生四烯酸氨基乙醇，AEA）是体内释放的一种大麻脂类衍生物，用于缓解疼痛。Enzo Life Sciences 提供大量与 endocannabinoid 通路相关的配体和抑制剂等，以及 cannabinoid receptors（CB1、CB2、and GPR55）相关受体。[查看]; http://cxbio.com/Article/Anandamide_1.html

抗平足蛋白，单抗 [生命科学]

: 单次跨模型糖蛋白质——平足蛋白（PDPN）是淋巴内皮和肺泡上皮的标记蛋白。另外，发现在脑肿瘤、恶性中皮肿瘤、睾丸肿瘤、卵巢癌和各种鳞状上皮癌中过量表达，参与肿瘤细胞的浸润和转移，表达量强弱与肿瘤的预后和浸润性有一定相关性。抗平足蛋白，单抗（LpMab-19），是识别 PLAG4 近域的 Thr76-Arg79 的抗体。抗平足蛋白，单抗（LpMab-21），是识别 PLAG4 近域的 Thr76-Arg79 的抗体。[查看]; http://cxbio.com/Article/PDPN_mab_1.html

重组抗体（rAb） [生命科学]

: 重组抗体（rAbs）比杂交瘤细胞生产的抗体具有许多优点。rAbs是通过体外的基因合成，因此可以在无动物源条件下生产。因为不依赖稳定的杂交瘤细胞系，可减低不必要的、非特异性结合的风险。由于核酸序列被明确定义且可以精确复制，因此rAbs的重复性高，产品批次间一致性也得到了提升。与传统抗体相比rAbs的结合更可靠，在短时间内更容易实现大批量生产。这些高特异性和灵敏性的抗体，可被广泛应用于各种实验。[查看]; http://cxbio.com/Article/rAb_1.html

关于肿瘤研究用抗体，你想了解的都在这里！ [生命科学]

: FUJIFILM Wako提供各种抗体，包括 Anti asialo GM1 (Rabbit)，助力癌症研究。[查看]; http://cxbio.com/Article/anti-asialo_1.html

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$Refractive Index @20℃-1.42009 Stabilised Sucrose$: Refractive Index @20℃-1.42009 Stabilised Sucrose

$Refractive Index at 20℃-1.43080 Stabilised Sucrose$: Refractive Index at 20℃-1.43080 Stabilised Sucrose

$Refractive Index @20℃-1.43080 Stabilised Sucrose$: Refractive Index @20℃-1.43080 Stabilised Sucrose

$Refractive Index at 20℃-1.44193 Stabilised Sucrose$: Refractive Index at 20℃-1.44193 Stabilised Sucrose

$Refractive Index @20℃-1.44193 Stabilised Sucrose$: Refractive Index @20℃-1.44193 Stabilised Sucrose

: N-亚硝基假木贼碱 (NAB)

: Hydrogen Peroxide 10% w/v stabilised

: TISAB for wine analysis (Dir. 2676/90) for the fluoride determination by selective electrodes.

: ABTS

: DTAB;十二烷基三甲基溴化铵

: CTAB;十六烷基三甲基溴化铵

: TTAB;十四烷基三甲基溴化铵

: 十八烷基三甲基溴化铵(STAB)

: Glycerol-3-phosphate Dehydrogenase,from rabbit muscle, suspension

: L-Lactate Dehydrogenase (L-LDH)from rabbit muscle, suspension

: Pyruvate Kinase,from rabbit muscle, suspension

: Triose-phosphate Isomerase,from rabbit muscle, suspension

: Pefabloc SC (AEBSF)

: 2,2'-azino-bis(3-ethylbenzthiazoline) 6-sulphonic acid (ABTS),solution

: Ethyclozate metabolite (CIA：5-Chloro-3 (1H)-indazolacetate)

: N-Nitrosoanatabine 2,4,5,6 D4， 10ng/ul 于丙酮

: European Pharmacopoeia Reagent 0.1M Tetrabutylammonium Hydroxide

: European Pharmacopoeia Reagent 0.1M Tetrabutylammonium Hydroxide in 2-propanol

: EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇

: EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇

: Gabapentin,1.0mg/mL 于甲醇

: MABM-LJ738-IGG

: MABM-TU11-IGG

: MABM-TU2-IGG Carcinoembryonic antigen

: MABM-TU3-IGG

: MAB M-7.4.5 IGG

: MAB M-6.12.47 IGG

: Mab Mix creatinine kinase isoenzyme MM

: MAB; M-1.2.57 IgG

: MAB; M-2.1.16 IgG,Human fibrinogen cleavage product D-Dimer

: MABM-3.170-IgG,Human liver ferritin

: MABM-4.184-IgG

: MABM-INN22-IgG Human chorionic gonadotropin b-chain

: MABM-INN2-IgG

: MABM-Tu66C7-IgG salivary α-amylase

: MABM-Tu88E8-IgG

: MABM-323-IgG

: MABM-7H8-IGG

: MABM-BM1-IgG

: MABM-ST3-IgG

: MABM-11412-IgG Luteinizing hormone

: MABM-2.406-IgG

: MABM-C4E4-IGG,Prolactin

: MABM-H12G10-IGG

: MABM-TU1.20-IGG

: PABS-Ig,Human C-reactive protein

: PABS-IGG,trijodothyronine

: PABS-IGG

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