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《Neuron》封面焦点文章揭示神经干细胞从胚胎维持到成年的新调控机制
2017年7月19日,清华大学医学院沈沁课题组在神经生物学顶级学术期刊《Neuron》上封面文章的形式在线发表了题为” Persistent expression of VCAM1 in radial glial cells is required for the embryonic origin of postnatal neural stem cells (VCAM1在放射状胶质细胞中的持续表达是神经干细胞从胚胎维持到成年的必要条件)”的研究论文。[查看]
http://cxbio.com/Article/neuronfmjdwzjssjgxbc_1.html
Adv Sci:新型siRNA纳米颗粒有效地逆转了肝损伤
重庆大学创新药物研究中心冯旭利教授及其研究团队在siRNA运输方面取得了重要进展。她们采用生物相容性良好的PEG作为主体框架,通过酸敏感的功能团采用无铜点击化学反应(Click Reaction)将siRNA通过共价键结合到主体材料上,该体系可大大提高siRNA的稳定性同时共价键的结合增加了siRNA的载药量.这些特征使得该体系不仅在细胞水平上,同时也在动物实验上实现了良好的特异性基因沉默,有效地逆转了肝损伤。[查看]
http://cxbio.com/Article/advscixxsirnanmklyxd_1.html
最新靶向疗法来袭,抗体偶联药物联合治疗有望治愈儿童白血病
近期,曼彻斯特大学的研究人员发现了导致最常见的儿童白血病产生化疗抵抗的幕后黑手5T4,它是存在在细胞表面的一种蛋白质。这也就意味着5T4或是治疗白血病的新靶点。对此,相关人员进行了实验研究,并且令人惊喜的是,早期的研究表明使用抗体偶联药物(ADC)靶向5T4蛋白可以有效改善儿童白血病的治疗。相关研究结果发表在《Haematologica》杂志上。[查看]
http://cxbio.com/Article/zxbxlflxktolywlhzlyw_1.html
西宝生物 Advanced ImmunoChemical代理证书
西宝生物 Advanced ImmunoChemical代理证书[查看]
http://cxbio.com/Article/xbswadvancedimmunoch_1.html
热烈庆祝西宝生物成为Advanced Immuno授权代理商!
西宝生物科技(上海)股份有限公司(以下简称西宝生物)与美国Advanced ImmunoChemical达成合作协议,西宝生物经授权正式成为Advanced Immuno授权代理,负责中国大陆地区的产品销售。[查看]
http://cxbio.com/Article/rlqzxbswcwadvancedim_1.html
PNAS:如何利用简单的血液检测来诊断癌症?
最近,一项发表在国际杂志Proceedings of the National Academy of Sciences上的研究报告中,来自普渡大学的研究人员通过研究表示,医生们未来或有望利用简单的血液检测来诊断和监测患者的癌症,从而或许就能够降低或消除一些侵入性手段的使用,文章中,研究者在血浆中鉴别出了一系列蛋白质,当这些蛋白水平升高时就意味着患者会患上癌症。[查看]
http://cxbio.com/Article/pnasrhlyjddxyjclzdaz_1.html
PNAS:科学家证实:诱导多能干细胞并不会增加遗传突变发生的概率
10多年前,日本科学家山中伸弥和其学生通过研究开发出了一种突破性的技术,能够将任何一种成体细胞转化成为多能干细胞,随后再使得这种新生的多能干细胞分化成为机体中不同类型的细胞。近日,一项刊登在国际杂志Proceedings of the National Academy of Sciences上的研究报告中,来自美国国家基因组研究所的研究人员通过研究表示,相比亚克隆复制的细胞而言,iPSCs似乎并不太会产生过多突变[查看]
http://cxbio.com/Article/pnaskxjzsyddngxbbbhz_1.html
PNAS:突破!科学家发现抗癌新方法!
日前,来自南安普敦大学的研究人员通过研究发现了机体免疫系统能够识别并且有效抵御癌症的重要途径,相关研究刊登于国际杂志Proceedings of the National Academy of Sciences上。 文章中,研究者发现了一种名为Akt的关键蛋白,该蛋白对于机体识别癌症的途径非常关键,机体的免疫系统中包括毒性T细胞,这种类型的T细胞能够主动寻找并且摧毁机体感染或者癌症,当毒性T细胞处理机体面临的危险时,大部分细胞都会死亡,剩下的T细胞就会转化成为记忆细胞,当相同危险再次袭击机体时这些记忆细胞[查看]
http://cxbio.com/Article/pnastpkxjfxkaxff_1.html
挑战常规!tau蛋白磷酸化起初是为了保护神经元
澳大利亚新南威尔士大学(UNSW)和澳大利亚神经科学研究所的研究人员进一步揭示了导致阿尔茨海默病(Alzheimer's disease, AD)的细胞过程,推翻了之前持有的关于这种疾病如何产生的观点,并且为开发能够阻止或延缓它的进展的新治疗方案打开大门。[查看]
http://cxbio.com/Article/tzcgtaudblshqcswlbhs_1.html
Circulation:重磅!科学家成功将结缔组织细胞重编程为心肌细胞
最近,来自格莱斯顿研究所(Gladstone Institutes)的科学家们通过研究鉴别出了两种化学物质或能改善心脏瘢痕组织转化成为健康心肌组织的能力,相关研究刊登于国际杂志Circulation上,该研究或将帮助研究人员开发新型有效的治疗心力衰竭的疗法。[查看]
http://cxbio.com/Article/circulationzbkxjcgjj_1.html
水熊虫特殊蛋白或帮助人类DNA抵御辐射损伤
缓步动物(Tardigrades),或者水熊虫是一种矮胖型的缓步动物门动物,在显微镜下其看起来介于蝴蝶幼虫和裸鼢鼠之间,这些水栖类无脊椎动物是一种完美的幸存者,其能够抵御一系列极端环境,包括近乎完全的脱水作用和损伤等。[查看]
http://cxbio.com/Article/sxctsdbhbzrldnadyfss_1.html
寻找阿尔茨海默病早期标志物
作为一种神经退行性疾病,阿尔茨海默病(Alzheimer's disease,AD)的特征在于显著的记忆丧失,也因此,它已成为大脑研究的焦点。鉴定早期诊断标志物在AD研究中至关重要。能够允许早期诊断AD的标志物是非常重要的[查看]
http://cxbio.com/Article/helps-97760936101_1.html
利用酮类物质治疗阿尔茨海默病
尽管几十年来努力开发一种预防或治愈阿尔茨海默病(Alzheimer's disease, AD)--折磨着老年人群的最为常见的痴呆症---的药物,但是当前还没有治疗这种破坏性疾病的方法。早在二十世纪二十年代,科学家们已发现促进酮生成(ketogenesis)的高脂肪饮食可控制癫痫症,而且酮生成仍然是治疗这种疾病的最为有效的方法之一。这就提高了酮类物质也对起源自异常神经代谢的其他疾病(如AD)提供神经保护作用的可能性。从那时起,就有研究证实酮类物质事实上确实改变脑部代谢,降低神经病变和缓解行为症状。[查看]
http://cxbio.com/Article/lytlwzzlaechmb_1.html
首个治疗儿童疾病的Strimvelis基因疗法在欧洲获批
近日,世界首个用于儿童治疗的基因疗法获得欧盟委员会(European Commission)批准,这项名为Strimvelis的基因疗法或将开启儿童疗法研究的新时代,相关研究刊登于国际杂志Blood上。该疗法可以治疗重症联合免疫缺陷(ADA-SCID)的患儿,这种疾病是一种非常罕见的儿童疾病,其在患儿受影响的极短时间内往往具有明显的致死率。[查看]
http://cxbio.com/Article/sgzletjbdstrimvelisj_1.html
「西宝生物」供应美国ChromaDex【中草药对照品】
美国 Chromadex 公司于1999年在加拿大成立,主要生产植物化学/中草药对照品以及标准材料,是植物参考标准的创造以及植物化学物质的产品和服务的供应商,西宝生物供应.[查看]
http://cxbio.com/Article/mgchromadexzcydzpyxb_1.html
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Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade II
D-乳酸脱氢酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮标准品
DADK嗪草酮标准品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化铝 (Reduction Grade) 标准物质
氧化铝 (Reduction Grade) 标准物质
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain