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肺癌脑转移的新机制
2023年8月17日,广州医科大学何建行及克利夫兰诊所鲍仕登共同通讯在Cancer Cell 在线发表题为“CD44+ lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration”的研究论文,该研究表明报道了肺腺癌(ADC)中来自CD44+肺癌干细胞(CSCs)的血管周细胞通过G蛋白偶联受体124 (GPR124)增强的跨内皮迁移(TEM)引起肿瘤脑转移。[查看]
http://cxbio.com/Article/fanzydxjz_1.html
Science:第一次确定了监督tau功能的基因
根据宾夕法尼亚大学佩雷尔曼医学院的一项新研究,一种编码与tau蛋白产生相关的蛋白的基因:TRIM11,在类似阿尔茨海默病(AD)的神经退行性疾病的小动物模型中被发现可以抑制恶化,同时提高认知和运动能力。此外,TRIM11被确定在去除导致神经退行性疾病(如AD)的蛋白缠结中起关键作用。研究结果发表在《科学》杂志上。[查看]
http://cxbio.com/Article/sciencedycqdljdtaugn_1.html
脂联素 糖尿病早期筛查的“新指标”
脂联素(ADPN)是由脂肪细胞分泌的、对人体有保护作用的特异性脂肪因子,人脂联素由244个氨基酸组成,是一种血浆含量相对丰富的蛋白,其基因位于染色体3q27,这也是糖尿病易感基因所在处,相对分子质量为30KD,是一种具有调节糖脂代谢、抗炎症反应、抗动脉粥样硬化等多重效应的脂肪细胞因子。[查看]
http://cxbio.com/Article/zlstnbzqscdxzb_1.html
阿尔兹海默症早期诊断标志物
阿尔兹海默症的检测主要有: 影像学检查、 脑脊液检测、神经心理学测验、脑电图检查。 AD早期诊断的生物标志物:Aβ42、Аβ42/ Aβ40、APPr、Aβ寡聚体、T-tau、P-tau、AD7c-NTP、NFL、VLP-1、hFABP、TGF-?、YKL-40、PGE2、IsoPs、miRNA-342-3p、Ferritin、Pb4等[查看]
http://cxbio.com/Article/aezhmzzqzdbzw_1.html
IL-17蛋白对皮肤老化的关键作用
来自巴塞罗那生物医学研究所(IRB Barcelona)与国家基因组分析中心(CNAG)合作的一组科学家发现,IL-17蛋白在皮肤老化中起着核心作用。这项研究由巴塞罗那IRB的Guiomar Solanas博士、Salvador Aznar Benitah博士和CNAG的Holger Heyn博士领导,强调了Il -17介导的衰老过程到炎症状态。[查看]
http://cxbio.com/Article/il17dbdpflhdgjzy_1.html
Science Advances:肝细胞影响生物钟的又一证据
昆士兰大学领导的一项研究表明,肝细胞会影响人体内部的生物钟,而此前人们认为生物钟完全由大脑控制。昆士兰大学分子生物科学研究所的fracimdsamric Gachon副教授和法国巴黎城市大学/CNRS的Serge Luquet博士及其合作者已经证明,移植了人类肝细胞的小鼠具有改变的昼夜节律。这项研究发表在《Science Advances》杂志上。[查看]
http://cxbio.com/Article/scienceadvancesgxbyx_1.html
血小板聚集功能检测——诱聚剂
血小板聚集是血小板的主要功能之一。 血小板在执行生理性止血作用的同时,在病理性血栓形成过程中起着先导而关键的作用,因此,检测血小板聚集功能对早期发现是否有血 栓形成的危险存在以及阐明相关疾病的机制等有重要意义。然而,仅采用单一诱聚剂检测时,可能无法完整的反映体检者的实际情况。西宝生物提供多种诱导血小板聚集的诱聚剂,包括胶原(Collagen)、花生四烯酸(arachidonicacid, AA)、二磷酸腺苷(adenosine diphosphate, ADP)和瑞斯托霉素(ristomycin,RIS)[查看]
http://cxbio.com/Article/AggregationAgents_1.html
Science子刊:世界首个能抵御致死性细菌感染的mRNA疫苗问世
近日,一篇发表在国际杂志Science Advances上题为“A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium”的研究报告中,来自以色列特拉维夫大学等机构的科学家们通过研究开发出了首个基于mRNA的疫苗,其或能100%有效抵御一种对人类致死的细菌。[查看]
http://cxbio.com/Article/sciencezksjsgndyzsxx_1.html
腺苷脱氨酶(<font color='red'>AD</font>A)检测试剂盒用原辅料
腺苷脱氨酶(ADA)测可以用于诊断多种疾病,如先天性免疫缺陷症候群(SCID)、HIV感染、结核病、肿瘤和肝胆等。腺苷脱氨酶(ADA)含量的测定方法,有过氧化物酶法、谷氨酸脱氢酶法等。西宝生物可提供腺苷脱氨酶(ADA)检测试剂盒用原辅料,咨询服务热线:400-021-8158或021-50272975。[查看]
http://cxbio.com/Article/ADAtest_Materials_1.html
<font color='red'>AD</font>C Linker之单分散氨基PEG Linker系列
在药物递送中,PEG可以用作抗体-药物偶联物(ADC)的连接体,或者用作纳米颗粒的表面涂层,以改善全身药物递送。研究发现,将单分散PEG插入小分子药物中,可以增加药物的溶解度和稳定性,从而延长药物在体内的半衰期,并可以减少高分子量PEG修饰聚合物时的空间位阻和结合作用,从而降低免疫原性,改善药代动力学,增加循环时间和降低毒性。[查看]
http://cxbio.com/Article/ADCLINKER_PEG_1.html
Nature Methods:新的亮红色荧光蛋白
荧光蛋白被广泛应用于生物学研究,使各种类型的细胞或结构可见。例如,与癌症有关的干细胞或蛋白质。由Dorus Gadella领导的阿姆斯特丹大学研究小组开发了一种新的鲜红色荧光蛋白:mScarlet3。他们在权威杂志《自然方法》上发表了这种蛋白质的特性和DNA代码。[查看]
http://cxbio.com/Article/naturemethodsxdlhsyg_1.html
Nature子刊:血管周围细胞诱发阿尔茨海默病相关的微胶质功能障碍
小胶质细胞是保护哺乳动物大脑的初级免疫细胞,部分是通过吞噬病原体和有毒碎片来实现的。最近的遗传学研究一直强调小胶质细胞在阿尔茨海默病(AD)和其他神经退行性疾病发展中的作用,表明它们可以异常地开始吞噬突触,神经元之间的关键连接。现在,伦敦大学学院(UCL)英国痴呆症研究所的研究人员进行了一项研究,旨在更好地了解小胶质细胞可以增加患AD风险的吞噬过程。[查看]
http://cxbio.com/Article/naturezkxgzwxbyfaech_1.html
《PNAS》科学家解开细胞存活之谜
拉霍亚免疫研究所(LJI)的研究人员终于发现了一种名为O-GlcNAc转移酶(OGT)的酶在维持细胞健康中的作用。这些发现发表在《美国国家科学院院刊》(Proceedings of The National Academies of Sciences)上,为细胞生物学提供了至关重要的见解,并可能为重大医学突破铺平道路。[查看]
http://cxbio.com/Article/pnaskxjjkxbchzm_1.html
阿尔兹海默与表观遗传之间的联系,干预“神经病”取得新进展
来自西奈山的科学家们对DNA甲基化在阿尔茨海默病(AD)中的作用提供了新的见解。根据他们的研究,DNA甲基化对AD相关基因和蛋白质的共表达网络有显著影响。因此,这可能会揭示新的神经病理过程和分子机制,最终导致阿尔茨海默病的创新治疗干预措施的发展。[查看]
http://cxbio.com/Article/aezhmybgyczjdlxgysjb_1.html
无路可退!主食中的农药残留,可诱发阿尔茨海默病
草甘膦是许多商业除草剂中的活性成分,是全球应用最广泛的除草剂。在小麦、水稻、玉米和大豆等作物中使用草甘膦的增加与阿尔茨海默病(Alzheimer’s disease,AD)和其他神经退行性疾病导致的死亡率增加呈正相关。此外,草甘膦暴露会增加血浆中的促炎细胞因子,尤其是TNFα(Tumor necrosis factor α)。草甘膦已被证明可以穿过血脑屏障,但尚未在体内得到验证。[查看]
http://cxbio.com/Article/wlktzszdnyclkyfaechm_1.html
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17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade II
D-乳酸脱氢酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮标准品
DADK嗪草酮标准品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化铝 (Reduction Grade) 标准物质
氧化铝 (Reduction Grade) 标准物质
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain