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PNAS:揭示SARS-CoV-2高传染性和隐蔽性的原因!
导致COVID-19的SARS-CoV-2病毒具有高度传染性。奇怪的是,在许多病人中,它会引起较差的免疫反应,从而延长疾病的时间。这有助于病毒的广泛传播,加剧了全球大流行。在发表在Proceedings of the National Academy of Sciences杂志上的一项新研究中,明尼苏达大学的研究人员发现了一种生物化学机制,这种机制或许可以解释这种病毒如何在有效感染人类的同时逃避免疫反应。[查看]
http://cxbio.com/Article/pnasjssarscov2gcrxhy_1.html
Lancet Infect Dis:MERS冠状病毒疫苗有望治疗MERS
近日,研究人员发现一种中东呼吸综合征冠状病毒疫苗在人体试验中展现出疗效,这可能有助于开发一种针对新型病毒的疫苗。该研究通讯作者、德国Hamburg-Eppendorf大学医学中心传染病部门负责人、DZIF科学家Marylyn Addo教授解释说:"疫苗试验的结果对于开发一种针对新型冠状病毒SARS-CoV-2的疫苗很重要,也让我们充满希望。中东呼吸综合征疫苗的开发为我们在DZIF快速开发针对新型冠状病毒的疫苗提供了基础。"[查看]
http://cxbio.com/Article/lancetinfectdismersg_1.html
Nat Med:迄今为止最大规模的蛋白质组学研究揭示葡萄糖代谢蛋白与阿尔兹海默病之间的神秘关联!
如今我们对阿尔兹海默病的病理生理学机制了解地仍然并不完全,近日,一篇发表在国际杂志Nature Medicine上题为“Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation”的研究报告中,来自埃默里大学医学院等机构的科学家们就通过利用定量质谱法和共表达网络分析技术进行了迄今为止最大规模的蛋白质组学研究将机体的葡萄糖代谢蛋白与阿尔兹海默病(AD)疾病生物学特性联系了起来。[查看]
http://cxbio.com/Article/natmedqjwzzdgmddbzzx_1.html
Cancer Res:胰腺癌细胞或会分泌特殊信号来阻断机体对肿瘤的免疫攻击
近日,一篇发表在国际杂志Cancer Research上的研究报告中,来自纽约大学等机构的科学家们通过研究发现,一种关键的免疫信号或在关闭免疫系统攻击胰腺癌上扮演着此前未知的角色,文章中,研究人员发现,免疫信号蛋白—白细胞介素1β(IL-1β)能被胰腺肿瘤细胞制造并释放,同时其会降低机体的抗癌免疫反应,从而促进胰腺导管腺癌(PDA,pancreatic ductal adenocarcinoma)的生长,PDA是一种通常会在两年内致命的癌症类型。[查看]
http://cxbio.com/Article/cancerresyxaxbhhfmts_1.html
Nature子刊:开发安全且有一定疗效的HIV疫苗
近日来自美国亨利·杰克逊军事医学发展基金会和沃尔特·里德陆军研究所美国军方艾滋病毒研究项目组的研究人员在Nature Medicine上发表了一篇题为"Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption"的文章。[查看]
http://cxbio.com/Article/naturezkkfaqqyydlxdh_1.html
BAFF,APRIL生物标志物-自身免疫性疾病系列专题
西宝生物作为一家生命科学领域的综合服务商,可提供自身免疫疾病研究整体解决方案包括BAFF(B细胞活化因子),APRIL(增殖诱导配体)重组蛋白、抗体、ELISA试剂盒、CD40特异性抗体(AdipoGen)和CD40L高活性蛋白(Miragen),咨询热线:400-021-8158[查看]
http://cxbio.com/Article/baffaprilzsmyxjbxlzt_1.html
Science子刊:揭示癌细胞多药耐药的新机制
韩国科学技术研究院(KAIST)的研究人员已经确定了对一线化疗的获得性耐药转移到二线靶向治疗的机制,这种机制导致了癌症耐药的"多米诺效应"。他们的研究发表在近日的《Science Advances》上,该研究提出了一种新策略,用于改善对抗癌药物产生耐药性的患者的癌症治疗的二线疗法。[查看]
http://cxbio.com/Article/sciencezkjsaxbdynydx_1.html
Nature Genetics: <font color='red'>AD</font>AMTS19缺失导致进行性非综合征性心脏瓣膜病
近日,加拿大蒙特利尔大学等科研机构的研究人员在Nature Genetics上发表了题为“Loss of ADAMTS19 causes progressive non-syndromic heart valve disease”的文章,发现ADAMTS19缺失导致进行性非综合征性心脏瓣膜病。[查看]
http://cxbio.com/Article/naturegeneticsadamts_1.html
PNAS:科学家有望开发出治疗艰难梭菌感染的新型药物疗法
近日,一项刊登在国际杂志Proceedings of the National Academy of Sciences上的研究报告中,来自纽约市立大学等机构的科学家们通过研究或有望帮助开发治疗艰难梭菌(clostridium difficile)感染的新药,艰难梭菌会引发腹泻、恶心、内出血和潜在死亡,其对公众健康会带来严重威胁,每年在美国这种细菌都会感染大约50万人,而且会造成1.5万人死亡。[查看]
http://cxbio.com/Article/pnaskxjywkfczljnsjgr_1.html
阿尔茨海默症与β淀粉样蛋白的前生今世
阿尔茨海默症(Alzheimer disease;AD)患者的大脑中,老人斑是显著的病理特征之一,是不溶性蛋白质异常聚集形成丰富的β片层结构的淀粉样纤维,并积累于脑实质细胞间隙的构成物。老人斑被认为是AD发病过程中的早期病变。1985年Masters等人开始研究老人斑淀粉样蛋白,对其进行分离纯化和氨基酸测定,证实老人斑的主要构成成分为β-淀粉样蛋白多肽(Aβ)。[查看]
http://cxbio.com/Article/aechmzydfydbdqsjs_1.html
Mol Cancer Res:鉴别出关键靶点有望开发出治疗三阴性乳腺癌的新型疗法
日前,一项刊登在国际杂志Molecular Cancer Research上的研究报告中,来自Lady Davis研究所的科学家们通过研究鉴别出了一种特殊蛋白,其在恶性乳腺癌对化疗产生耐药的过程中扮演着非常关键的角色,相关研究结果有望帮助开发克服乳腺癌药物耐受性的新型策略。[查看]
http://cxbio.com/Article/molcancerresjbcgjbdy_1.html
Science:重磅!突破性的HIV疫苗设计策略崭露头角
在一项新的研究中,来自美国斯克里普斯研究所等研究机构的研究人员成功地对一种先进的HIV疫苗策略进行了原理验证,这种方法也可能有效地保护人们免受其他他致命性传染病的侵害。相关研究结果近期发表在Science期刊上,论文标题为“A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses”。[查看]
http://cxbio.com/Article/sciencezbtpxdhivymsj_1.html
【外泌体纯化】新型亲和法外泌体提取试剂盒 ——MagCapture 外泌体提取试剂盒PS
MagCapture™外泌体提取试剂盒 PS采用磷酯酰丝氨酸(PS)亲和Tim4蛋白固化磁珠(PS亲和法)的方法可以简便快捷地提取高纯度的完整外泌体和其他细胞外囊泡(EVs)。如果想要得到更高纯度的外泌体,请使用10,000×g离心后的上清。西宝生物作为Wako指定国内经销商可提供外泌体研究整体解决方案,咨询请拨打400-021-8158[查看]
http://cxbio.com/Article/xxqhfwmttqsjhmagcapt_1.html
二噁英分析专用硅胶填料
西宝生物携手wako二噁英分析产品线也已服务于国内客户近十年,为国内二噁英检测分析提供整体的解放方案,除了能提供用于二噁英分析用吸附柱,还提供能用于填充柱子中的二噁英吸附填料。包括用于二噁英吸附的吸附树脂(Dioxin Trap Beads),用于制备多层硅胶柱的2%氢氧化钾硅胶、10%硝酸银硅胶、44% 硫酸硅胶、22% 硫酸硅胶、硫酸钠等,用于制备活性炭埋藏硅胶柱的活性炭埋藏硅胶等。这些填料都具有良好的渗透性和对二噁英的良好吸附能力。[查看]
http://cxbio.com/Article/efyfxzygjtl_1.html
Adv Sci:研究人员描述了一种诱导癌细胞自我杀伤的机制
研究人员描述了一种新的机制,通过干扰离子稳态诱导癌细胞的自我杀伤。韩国科学技术研究院生化工程系的一个研究小组开发了螺旋多肽钾离子载体,可导致程序性细胞死亡。离子载体增加活性氧浓度,使内质网应激至细胞死亡。[查看]
http://cxbio.com/Article/advsciyjrymslyzydaxb_1.html
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Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade II
D-乳酸脱氢酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮标准品
DADK嗪草酮标准品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化铝 (Reduction Grade) 标准物质
氧化铝 (Reduction Grade) 标准物质
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain