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Cell发文提出肿瘤治疗新方向:药物干预RNA剪接可增强肿瘤免疫
2021年6月24日,国际学术期刊《细胞》杂志在线发表了美国弗雷德哈钦森癌症研究中心Robert K. Bradley和纪念斯隆凯特琳癌症中心Omar Abdel-Wahab团队名为“Pharmacologic modulation of RNA splicing enhances anti-tumor immunity”的合作研究,该研究证实了药物干预RNA剪接对抗肿瘤免疫的增强作用。[查看]
http://cxbio.com/Article/cellfwtczlzlxfxywgyr_1.html
阻止认知及听力衰退,Plo Bio新文给出新思路:血液中的这种蛋白质是关键
近日,美国德克萨斯大学麦戈文医学院带来的一项研究报告从分子机制上为人们了解影响衰老程度的关键因子提供了新的思路。文章指出,血液红细胞中一种被称为腺苷A2B受体(ADORA2B)的蛋白质是抗衰老的关键成分之一,该蛋白质的缺乏或过度消耗会加速人体功能组织衰老,造成记忆力快速下降、听力退化以及大脑炎症加剧。[查看]
http://cxbio.com/Article/zzrzjtlstplobioxwgcx_1.html
KRAS抑制剂adagrasib获FDA突破性疗法认定!
Mirati Therapeutics公司宣布,美国FDA已经授予该公司开发的KRAS G12C抑制剂adagrasib突破性疗法认定,用于治疗携带KRAS G12C突变的经治非小细胞肺癌(NSCLC)患者。[查看]
http://cxbio.com/Article/krasyzjadagrasibhfda_1.html
Nature 最新研究:硬核预防HIV,艾滋病还会是“不治之症”吗?
近日,美国俄勒冈健康与科学大学研究团队在 Nautre 子刊发表了题目为 Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission 的文章。其研究显示,人源化CCR5单克隆抗体 Leronlimab 能够有效预防恒河猴等非灵长类动物感染猿/人HIV病毒,这一研究成果将为人类预防HIV病毒感染提供新的临床治疗途径。[查看]
http://cxbio.com/Article/naturezxyjyhyfhivazb_1.html
Nature 三连重磅!识破癌细胞的“诡计”,为结直肠癌患者带来新希望
近日, 顶级学术期刊《Nature》三连发表重磅文章拆穿了癌细胞的“把戏”,为结肠癌高危人群提供了新的预防策略。同时,《Nature》还在线发表题为Cancer stem cells in the gut have a bad influence on neighbouringcells的 News & Views,提供了有关癌细胞及其邻近细胞在肠道中的竞争动态的重要见解。[查看]
http://cxbio.com/Article/natureslzbspaxbdgjwj_1.html
神奇!新研究揭示:神经系统或可替代抗生素抑制细菌感染
近日,《Plos Pathogens》杂志发表了一篇题为UPEC kidney infection triggers neuro-immune communication leading to modulation of local renal inflammation by splenic IFNγ的文章,揭示了神经系统感知局部细菌感染并迅速激活免疫反应的新机制。[查看]
http://cxbio.com/Article/sqxyjjssjxthktdkssyz_1.html
Cell子刊揭示:中药成分可促进脂肪产热,或可用于治疗肥胖
近日,国际学术期刊《细胞-代谢》在线发表了上海市第六人民医院糖尿病研究所刘军力课题组题为“The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity”的研究。该研究发现,传统中药贯叶连翘的提取物贯叶金丝桃素能够促进脂肪组织产热。[查看]
http://cxbio.com/Article/cellzkjszycfkcjzfcrh_1.html
还在根据碳水含量选择饮食?NEJM揭示:这个指标才是重中之重
近日,NEJM在线发布了加拿大营养科学部的研究人员题为Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality的研究成果。该研究通过大量数据随访揭示了来自五大洲的不同收入水平的人群中血糖指数与心血管疾病之间关系,填补了低收入和中等收入国家关于这一方面研究的空白。[查看]
http://cxbio.com/Article/hzgjtshlxzysnejmjszg_1.html
糖尿病患者的福音来了!《BMC》发文:NCAS可作为饮食糖替代品
近日,《BMC》发布了一篇题为High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice的文章,发现人和小鼠短期内食用糖精量在最大可接受水平(ADI)时,不会改变其肠道菌群稳态或引起葡萄糖耐受不良。[查看]
http://cxbio.com/Article/tnbhzdfyllbmcfwncask_1.html
Nature子刊:想要健康减肥,首选低脂高碳水饮食,还是高脂低碳水饮食?
近日,来自美国国立糖尿病、消化与肾脏疾病研究所和美国国立卫生研究院的科研人员在《Nature Medicine》上发表了题为Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake的研究成果,发现相比动物性低碳水高脂饮食,植物性低脂高碳水饮食每天摄入的能量更少,但胰岛素和血糖水平确实更高。[查看]
http://cxbio.com/Article/naturezkxyjkjfsxdzgt_1.html
Cell子刊:减肥能增加骨质量,或成新的抗骨质疏松治疗策略
2020年10月6日,美国华盛顿大学医学院 Steven L. Teitelbaum 团队在国际学术期刊《 细胞—代谢 》上发表题为“ Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain ”的文章,揭示了 成年小鼠脂肪细胞的消除能够诱导大量的骨增加。[查看]
http://cxbio.com/Article/cellzkjfnzjgzlhcxdkg_1.html
Nature子刊:超5万人研究发现人体内神奇的棕色脂肪可预防多种慢性疾病!
近日,来自美国洛克菲勒大学的研究人员在《Nature Medicine》上发表了题为Brown adipose tissue is associated with cardiometabolic health的研究成果,在这项超过52,000名参与者的大规模研究中,明确了BAT在促进心脑血管代谢健康中具有潜在作用,含有BAT个体的心血管疾病及2型糖尿病等的患病风险明显较低。[查看]
http://cxbio.com/Article/naturezkc5wryjfxrtns_1.html
Science子刊:利用智能手机超灵敏定量检测唾液中的新冠病毒
根据一项新的研究,一种基于唾液的便携式智能手机平台为COVID-19测试提供了一种超灵敏但易于使用的方法,它可以在15分钟内给出测试结果,而无需进行当前金标准所需的资源密集型实验室测试。该方法在12名COVID-19感染者和6名健康对照者中进行了测试。相关研究结果于2020年12月11日在线发表在Science Advances期刊上,论文标题为“A smartphone-read ultrasensitive and quantitative saliva test for COVID-19”。论文通讯作者为美国杜兰大学医学院的Tony Y. Hu博士。[查看]
http://cxbio.com/Article/sciencezklyznsjclmdl_1.html
Science子刊:环氧水解酶抑制剂可降低神经炎症,有望治疗阿尔茨海默病
神经炎症与阿尔茨海默病(Alzheimer’s disease, AD)密切相关。越来越多的人已认识到神经炎症在AD起着关键作用。环氧脂肪酸(epoxy fatty acid, EpFA)是花生四烯酸代谢途径的衍生物,具有抗炎活性。然而,由于EpFA被可溶性环氧水解酶(soluble epoxide hydrolase, sEH)快速水解,它们的功效受到限制。在一项新的研究中,来自美国贝勒医学院的研究人员报道sEH主要在星形胶质细胞中表达,并在AD患者的死后大脑组织和5xFAD β淀粉样蛋白AD小鼠模型中升高。这种AD小鼠模型大脑中表达的sEH数量与大脑EpFA浓度下降有关。[查看]
http://cxbio.com/Article/sciencezkhysjmyzjkjd_1.html
Nature子刊解读!科学家们开发出能高效检测人类脂肪肝和肝纤维化新型探测器!
大约25%的美国人都会患上脂肪肝,这种疾病会导致肝脏纤维化, 最终会导致肝功能衰竭;目前并没有简便的方法来诊断脂肪肝或肝纤维化,近日,一篇发表在国际杂志Nature Biomedical Engineering上题为“A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis”的研究报告中,来自麻省理工学院等机构的科学家们通过研究基于核磁共振技术(NMR)开发出了一种新型诊断工具,其或能用来诊断上述两种肝脏疾病。[查看]
http://cxbio.com/Article/naturezkjdkxjmkfcngx_1.html
记录总数:709 | 页数:48  <...36373839404142434445...>  
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Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade II
D-乳酸脱氢酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮标准品
DADK嗪草酮标准品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化铝 (Reduction Grade) 标准物质
氧化铝 (Reduction Grade) 标准物质
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain