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Nature Medicine:重新认识APOE4和阿尔茨海默病
西班牙圣保罗生物医学研究所领导的研究团队近日发现,对于携带两个APOE4基因拷贝(APOE4纯合子)的个体,几乎所有人都表现出阿尔茨海默病(AD)的病理特征。[查看]
http://cxbio.com/Article/naturemedicinezxrsap_1.html
Adhesamine - 促进细胞增殖和细胞粘附的低分子量化合物
Adhesamine是促进培养容器中的细胞粘附和细胞增殖的低分子化合物。参与细胞表面的硫酸乙酰肝素的结合,显示与纤连蛋白相似的细胞粘附作用。它可以通过添加在培养基中或培养容器的涂层,能使培养容器中的浮游细胞贴壁。附着于含本产品培养容器的细胞,换成不包含本产品的培养基中,即可从培养容器中剥离。HeLa, HEK293, CHO, 小鼠ES细胞等已确认效果[查看]
http://cxbio.com/Article/adhesamine_1.html
《Science Advances》CRISPR-Cas9利用低温休克肿瘤细胞靶向肺癌
浙江大学的科学家们已经开发出一种新的CRISPR-Cas9递送载体,在治疗肺癌方面比脂质纳米颗粒(LNPs)更有效。快速液氮治疗可以将肿瘤细胞转化为体内靶向癌症的基因编辑工具的载体。低温休克在保留肿瘤细胞结构和表面受体功能的同时,消除了肿瘤细胞的致病性。[查看]
http://cxbio.com/Article/scienceadvancescrisp_1.html
发现阿尔茨海默病的新治疗靶点PDE4B 活性降低27%可大大挽救<font color='red'>AD</font>小鼠记忆、大脑功能和炎症
英国利兹大学和兰开斯特大学的研究人员发现了治疗阿尔茨海默病的一个新的潜在靶点——PDE4B。文章发表在《自然》旗下的《 neuropsychopharmacology》期刊上。研究发现,阿尔茨海默(AD)小鼠在迷宫测试中表现出记忆缺陷,但PDE4B基因活性降低的AD小鼠的记忆没有受损。这提示减少PDE4B活性不仅可以预防阿尔茨海默病,还可以预防其他形式的痴呆症,如亨廷顿氏病的认知障碍的前景。[查看]
http://cxbio.com/Article/20240327_industrialnews_1.html
《Cell Stem Cell》改变游戏规则的类器官模型
在南加州大学干细胞科学家的首次研究中,Giorgia Quadrato实验室开创了一种新的人类大脑类器官模型,该模型产生了小脑的所有主要细胞类型,小脑是一个后脑区域,主要由运动、认知和情感所必需的两种细胞类型组成:颗粒细胞和浦肯野神经元。[查看]
http://cxbio.com/Article/cellstemcellgbyxgzdl_1.html
Seebio(R) 烟酰胺单核苷酸应用
在细胞内,尼克酰胺单核苷酸(NMN)是烟酰胺腺嘌呤二核苷酸(NAD+)的重要前体。NAD+是一种在细胞内参与多种生物化学反应的辅酶,对于维持细胞正常功能和代谢至关重要。因此,NMN在细胞内具有重要的生物学意义。[查看]
http://cxbio.com/Article/seebioryxadhgsyy_1.html
Nature令人着迷的新发现:DNA复制时序
复制遗传信息的复杂过程被称为DNA复制,是生命从一个细胞传递到另一个细胞、从一个生物体传递到另一个生物体的核心。这不仅仅是简单的复制遗传信息,还是一个精心安排的分子事件序列,必须在正确的时间发生。来自慕尼黑亥姆霍兹大学的Maria-Elena Torres-Padilla教授研究组最近发现了这个过程的一个迷人之处,即“复制时序”(RT,replication timing),以及生命开始时这一过程的特殊性。新的研究结果发表在《自然》杂志上。[查看]
http://cxbio.com/Article/naturelrzmdxfxdnafzs_1.html
Biostir(R)特应性皮炎诱导剂<font color='red'>AD</font>
Biostir(R)特应性皮炎诱导剂AD,是特应性皮炎相关的房尘螨提取物成分之一,能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤。[查看]
http://cxbio.com/Article/Biostir_1.html
腺病毒抗原(HAdV)-免疫层析(胶体金及彩色乳胶)解决方案
本文所述人腺病毒抗原检测试剂是指利用胶体金免疫层析法或彩色乳胶免疫层析法等基于抗原抗体反应原理,针对婴幼儿粪便标本中的腺病毒抗原进行体外定性检测的试剂,辅助医生诊断。[查看]
http://cxbio.com/Article/HAdV-immunotest_1.html
重组人MEGACD40L(R) 蛋白(可溶)
MEGACD40L是一种高活性蛋白,是两个三聚体CD40配体分子通过Adiponectin/ACRP30/AdipoQ的胶原域人工连接而成。在体内,这种蛋白质能有效的模拟CD40L的天然膜辅助聚合。可简单有效的替代 [CD40L+增强剂]组合[查看]
http://cxbio.com/Article/MEGACD40L_1.html
Science Advances:叶绿体的作用不仅仅是光合作用!免疫防御中隐藏的玩家
科学家们早就知道叶绿体可以帮助植物将太阳能转化为食物,但由加州大学戴维斯分校的植物生物学家领导的一项新研究表明,叶绿体对于植物免疫病毒和细菌病原体也是必不可少的。[查看]
http://cxbio.com/Article/20231027_industrialnews_1.html
高质量DNA Ladder
DNA?Ladder是琼脂糖或丙烯酰胺凝胶电泳中使用的不同长度的DNA分子的溶液,将DNA Ladder和DNA样品同时加入到凝胶中,根据DNA样品条带与DNA?Ladder条带的位置和明亮度比较,可以参考和估计分离的未知DNA分子的大小。DNA?Ladder是每个DNA处理实验室经常使用的基本分子。西宝生物提供多种类型高质量DNA Ladder,现货供应,咨询服务热线:400-021-8158或021-50272975[查看]
http://cxbio.com/Article/gzldnaladder_1.html
脂质过氧化研究的新工具 - LipiR<font color='red'>AD</font>ICAL Green(检测试剂)/OH-Pen(抑制物质)
LipiRADICAL Green是特异性荧光检测脂质过氧化反应的上游因子脂质自由基的试剂。可用于活细胞成像、样品中脂质自由基含量的相对定量以及样品中脂质自由基的结构分析和全面鉴定。另外,OH-Pen还可作为脂质自由基特异性中和剂使用。[查看]
http://cxbio.com/Article/LipiRADICAL_Green_1.html
抗dFoxO多克隆抗体
Forkhead 转录因子 FoxO 控制参与细胞周期,细胞死亡,代谢和氧化应激的各种细胞过程。 最近的研究还提示 FoxO 是各种生物体的寿命调节的关键分子。 果蝇具有单个 FoxO基因(dFoxO),其失活对于存活不构成影响。 然而,dFoxO 似乎调节抵抗氧化应激和果蝇的衰老。 由于 dFoxO 的活性受磷酸化,泛素化和乙酰化调节,在使用该抗体的免疫印迹实验中可能出现多个 dFoxO 的条带。 该抗体可检测总 dFoxO 蛋白的内源水平。[查看]
http://cxbio.com/Article/anti-dFoxO_1.html
Nature:利用CRISPR,终于弄清楚了一种独特的免疫细胞是如何识别并摧毁肿瘤的
γ-δT细胞是免疫系统中的一种特殊类型的细胞,在识别和杀死癌细胞方面非常有效。肿瘤中这些T细胞水平较高的癌症患者往往比那些水平较低的患者情况要好。但科学家们一直在努力弄清楚γ-δT细胞是如何识别癌细胞的,以及新的癌症疗法如何能够利用这些强大的免疫细胞。现在,Gladstone研究所和加州大学旧金山分校的研究人员已经确定了γ-δT细胞识别癌细胞的条件。这项研究发表在《自然》杂志上。[查看]
http://cxbio.com/Article/20230901_1.html
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Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型辅酶I|烟酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade I
D-乳酸脱氢酶(D-LDH), Grade II
D-乳酸脱氢酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮标准品
DADK嗪草酮标准品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化铝 (Reduction Grade) 标准物质
氧化铝 (Reduction Grade) 标准物质
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain